Nigel Yarlett

Personal Quote

"In the fields of observation chance favors the prepared mind." Louis Pasteur.

Faculty Bio

Awarded a Fellow of the Royal Society of Chemistry (2012); Fellow of the Society of Fellows of Pace University (1996); Hutner Prize in Protozoology (1995); Kenan Teaching Award (2003); Lady Glanely Scholarship (1978). Over 100 publications in the area of protozoan biochemistry. Demonstrated the presence of hydrogenosomes in Rumen protozoa and Rumen fungi. The role of oxygen in the resistance of Trichomonas vaginalis to metronidazole. The unique polyamine bichemistry of Trichomonas vaginalis and Cryptosporidium parvum. The ability of oxoboroles to cure mouse model trypanosomiasis. Novel culture method for Cryptosporidium parvum. Funded by the National Institutes of Health; Drugs for Neglected Diseases initiative, and the Bill and Melinda Gates Foundation.

Awards and Honors

• Royal Society of Chemistry, 2012, Fellow of the Royal Society of Chemistry
• Pace University, 2003, Kenan Award for Teaching Excellence
• Pace University, 1996, Fellow of the Society of Fellows of Pace University
• International Society for Protistology, 1996, Hutner Prize
• University of Wales, 1978, Lady Glanely Scholarship

Licensures and Certificates

• NYSDOH, Radiation Safety Officer University RSO responsible for ensuring compliance with City, State and Federal guidelines. First responder in NYC for radiation emergency.

University of Wales Fellowship, Cardiff University, Cardiff, Wales, UK, 1986
Biochemical Parsitology

Visiting Fellow, Cambridge University, United Kingdom, 1986
Anaerobic Biochemistry

Post-Doctoral, Rockefeller University, New York, 1984
Biochemical Cytology

PhD, Cardiff University/Hannah Research Institute, Cardiff, Wales/ Ayr, Scotland, 1982
Biochemistry

BS, Cardiff University, Cardiff, Wales, UK, 1979
Microbiology

Research Interest

My Research is focused on the biochemistry and molecular biology of parasitic protozoa, particularly Cryptosporidia sp., and Trypanosomes. My research has resulted in the development of a new class of compound, the oxaboroles, to treat human African trypanosomiasis (HAT) that is currently in phase II clinical trials in Africa. I am also developing a novel culture system to facilitate the screening of novel compounds for the treatment of cryptosporidosis.

Past Courses

BIO 480: Research in Biology
BIO 610: Biochem & Adv Molecular Bio
BMB 601: Graduate Colloquium
BMB 605: Scientific Communications
BMB 609: Special Topics in BMB
BMB 610: Seminar
BMB 620: Quantitative Methods
BMB 629: Molecular Biochemistry
BMB 710: Research I
BMB 711: Research II
BMB 712: Thesis Preparation
CHE 101: Introduction to Chemistry I
CHE 103: Elements of Chemistry I
CHE 107: Forensic Chemistry I
CHE 326: Biochemistry
CHE 326: Biochemistry (Lecture Only)
CHE 328: Advanced Biochemistry
CHE 329: Adv Biochemistry Laboratory
CHE 330: Advanced Inorganic Chemistry
CHE 395: Independent Study in Chemistry
CHE 480: Research in Chemistry
ENS 772: Thesis Preparation
ENS 792: Rsrch in Envrnmntl Sci I
ENS 793: Rsrch in Envrnmntl Sci II
ENS 798: Tpc: Environmental Science
FOR 503: Biochem & Molecular Biology
FOR 503: Biochemistry
FOR 799: Thesis II

Publications

Continuous culture of Cryptosporidium parvum using hollow fiber technology
Morada, M., Lee, S., Gunther-Cummins, L., Weiss, L., Widmer, G., Tzipori, S. & Yarlett, N. International Journal of Parasitology. Vol in press

Intellectual Property

Patent: Treatment of diseases caused by parasitic protozoa and fungal diseases by administration of 5'-deoxy-5'-(substituted) ethylthioribose compounds [Non-Provisional] , United States

Patent: Adenosine compounds for the treatment of diseases caused by parasitic protozoa [Non-Provisional] , United States

Patent: 5'Deoxy-5'-(substituted) alkylthioribose compounds and their pharmaceutical compositions. [Non-Provisional] , United States

Professional Memberships

• Royal Society of Chemistry [Fellow]
• New York Academy of Science
• American Society for Biochemistry and Molecular Biology [Member]
• International Society for Protistologists [Member at Large, Editorial Board, Treasurer]
• Society for General Microbiology [Editor]